AF-B STEP: Global collaboration to reduce the burden of atrial fibrillation and advance quantification and treatment

Atrial fibrillation (AF) affects millions of people worldwide – yet the condition is rarely quantified upon diagnosis. The international research project AF-B-STEP aims to change this: for the first time, it will systematically assess how much time individuals spend in AF, expressed as their AF burden, and determine the extent to which the AF burden influences the risk of stroke, heart failure and other aspects of patients´ lives.

Transforming Atrial Fibrillation Management by Targeting Comorbidities and Reducing Atrial Fibrillation Burden – an AFNET/EHRA position paper

Patient:innen mit einem akuten Schlaganfall und gleichzeitig bestehendem Vorhofflimmern haben ein besonders hohes Risiko für einen erneuten Schlaganfall und andere schwerwiegende kardiovaskuläre Ereignisse. In einer europaweiten klinischen Studie unter Leitung von Wissenschaftler:innen des Universitätsklinikums Hamburg-Eppendorf (UKE) wird jetzt  geprüft, ob eine frühe rhythmuserhaltende Behandlung Schlaganfälle effektiv und sicher verhindern kann.  Die EU fördert das Projekt in den kommenden sechs Jahren mit sieben Millionen Euro.

AF burden on early rhythm control modulates patient outcomes

An analysis of patient-operated ECGs from the EAST – AFNET 4 trial revealed: A low AF burden below 6% in the first year of early rhythm control therapy was associated with low cardiovascular event rates during the subsequent 4 years of follow-up. Patients with a higher AF burden on early rhythm control suffered more AF-related events. Today the findings were presented by AFNET board member Prof. Ulrich Schotten, Maastricht University, in a hotline session at the annual congress of the European Society of Cardiology (ESC) in Madrid (1,2).