Can smartphones play a decisive role in advancing personalized cardiology? In the interview series “Digital Impulses,” Larissa Fabritz from the University Heart and Vascular Center Hamburg discusses the possibilities of early cardiological detection using smartphones.
Atrial fibrillation (AF) affects millions of people worldwide – yet the condition is rarely quantified upon diagnosis. The international research project AF-B-STEP aims to change this: for the first time, it will systematically assess how much time individuals spend in AF, expressed as their AF burden, and determine the extent to which the AF burden influences the risk of stroke, heart failure and other aspects of patients´ lives.
Patient:innen mit einem akuten Schlaganfall und gleichzeitig bestehendem Vorhofflimmern haben ein besonders hohes Risiko für einen erneuten Schlaganfall und andere schwerwiegende kardiovaskuläre Ereignisse. In einer europaweiten klinischen Studie unter Leitung von Wissenschaftler:innen des Universitätsklinikums Hamburg-Eppendorf (UKE) wird jetzt geprüft, ob eine frühe rhythmuserhaltende Behandlung Schlaganfälle effektiv und sicher verhindern kann. Die EU fördert das Projekt in den kommenden sechs Jahren mit sieben Millionen Euro.
An analysis of patient-operated ECGs from the EAST – AFNET 4 trial revealed: A low AF burden below 6% in the first year of early rhythm control therapy was associated with low cardiovascular event rates during the subsequent 4 years of follow-up. Patients with a higher AF burden on early rhythm control suffered more AF-related events. Today the findings were presented by AFNET board member Prof. Ulrich Schotten, Maastricht University, in a hotline session at the annual congress of the European Society of Cardiology (ESC) in Madrid (1,2).
A Win Ratio analysis confirmed the primary result of the NOAH – AFNET 6 trial and did not find an advantage of anticoagulation with edoxaban over no anticoagulation in patients with device-detected atrial fibrillation. Clinical decisions should therefore be guided by individual factors. The findings were presented by Dr. Nina Becher, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, in a hotline session at the annual congress of the European Society of Cardiology (ESC) in Madrid. (1,2)
Patients with an acute stroke and atrial fibrillation have a particularly high risk of a recurrent stroke and other serious cardiovascular events. A Europe-wide clinical trial led by scientists from the University Medical Centre Hamburg-Eppendorf (UKE) is now investigating whether early rhythm-control treatment can effectively and safely prevent strokes.
Many patients with atrial fibrillation (AF) experience stroke, cardiovascular death and other cardiovascular complications. Early rhythm control can prevent some of these events but is often withheld from elderly patients with multiple comorbidities. Catheter ablation is the most effective rhythm-controlling therapy but has mainly been tested in younger patients. The German Atrial Fibrillation Network (AFNET) initiated the EASThigh – AFNET 11 trial to investigate whether early catheter ablation can reduce outcomes in patients with AF and comorbidities. EASThigh – AFNET 11 enrolled the first patient on 14.10.2024.
Atrial fibrillation (AF) epidemic affects the health of a growing number of people worldwide. Patients with AF are at risk of stroke, heart failure, death and dementia. Many patients develop AF in old age, and older people with cardiovascular comorbidities are at highest risk of AF-related complications.
A combined subgroup analysis of the similar trials NOAH – AFNET 6 (1) and ARTESiA (2) revealed: Patients with device-detected atrial fibrillation and concomitant vascular disease are at higher risk of stroke and cardiovascular events and may derive a greater benefit from oral anticoagulation than those without vascular disease. The finding was presented by AFNET Steering Committee member Prof. Renate Schnabel, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, at the annual congress of the European Society of Cardiology (ESC) in London on 02.09.2024 and published in the European Heart Journal (3).
Device-detected atrial fibrillation (DDAF) are short and typically rare episodes of atrial fibrillation (AF) detected by pacemakers, defibrillators, or implanted loop recorders. Device-detected atrial fibrillation is found in every fifth patient with a cardiac implanted electronic device (4). Device-detected atrial fibrillation can lead to stroke, but the stroke risk in patients with device-detected atrial fibrillation appears lower than the stroke risk in patients with ECG-documented atrial fibrillation (1%/year).
Low concentrations of three selected biomarkers in the blood of patients with atrial fibrillation identify patients with a high chance of attaining sinus rhythm. This is the main result of this analysis of the EAST – AFNET 4 biomolecule study. Today the findings have been presented by AFNET Steering Committee member Prof. Larissa Fabritz, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, at the annual congress of the European Society of Cardiology (ESC) in London and published in the European Heart Journal (1).
Atrial Fibrillation (AF) is the most common arrhythmia in senior people. AF often occurs in patients with cardiovascular comorbidities. Recurrent AF is determined by interactions between cardiovascular disease processes and rhythm-control therapy. Predictors of attaining sinus rhythm at follow-up are not well known.
An international cardiology working group has published a consensus report on atrial cardiomyopathy (1). 21 scientists from the rhythmological societies of Europe (European Heart Rhythm Association (EHRA)), North America (Heart Rhythm Society (HRS)), South America (Latin American Heart Rhythm Society (LAHRS)) and the Asia-Pacific region (Asia Pacific Heart Rhythm Society APHRS) were involved. The expert group was led by AFNET board member Prof. Andreas Goette, Paderborn, Germany. He presented the results on August 31, 2024 at the annual congress of the European Society of Cardiology (ESC) in London.
Atrial cardiomyopathy (AtCM) refers to pathological changes in the heart’s atria, including the atrial muscle cells. They contribute to the development of atrial fibrillation, can cause blood clots and strokes and are therefore of fundamental clinical importance.
