RESEARCH & PROJECTS SCIENCE & PROJECTS AFNET plans and conducts investigator-initiated studies, registries and research projects. Below you will find an overview of the current studies with AFNET as sponsor: 2030 2029 2028 2027 2026 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 … Read more
Diversity Statement The Atrial Fibrillation Competence Network is strongly committed to promoting diversity, inclusion and equality. We are convinced that a diverse and inclusive community not only improves the working environment, but also enriches the quality and scope of our scientific work. In our team, people of different ages, genders and professional backgrounds work closely … Read more
Gap-AF-AFNET 1 Catheter ablation of arial fibrillation by linear pulmonary vein isolation Study design Randomized trial to investigate the significance of complete versus incomplete electrical isolation of pulmonary veins by radiofrequency-induced linear lesions in patients with paroxysmal atrial fibrillation Inclusion Criteria Idiopathic paroxysmal symptomatic atrial fibrillation refractory to antiarrhythmic therapy Age 50 – 85 years … Read more
ANTIPAF-AFNET 2 Angiotensin II-Antagonist in Paroxysmal Atrial Fibrillation Trial (ANTIPAF Trial) Study design Prospective, randomized, placebo-controlled, multicenter trial analyzing the AF burden (percentage of days with documented episodes of paroxysmal AF) during a 12-month follow-up as the primary study end point. Four hundred thirty patients with documented paroxysmal AF without structural heart disease were randomized … Read more
Flec-SL-AFNET 3 Targeted Pharmacological Reversal of Electrical Remodeling After Cardioversion. Study design Prospective, randomized, controlled, open label, parallel group multi-center investigator-initiated trial. Inclusion Criteria Documented persistent atrial fibrillation Age of 18 years Documented oral anticoagulation (INR ≥ 2) for at least three weeks prior to inclusion, or exclusion of left atrial thrombi by trans-esophageal echocardiography … Read more
EAST-AFNET 4 Early treatment of atrial fibrillation for stroke prevention trial (EAST) study design Investigator-driven, prospective, parallel-group, randomised, open-label trial with blinded-outcome assessment (PROBE-Design). Multi-centre trial for Prevention of Stroke in High-risk Subjects with Atrial Fibillation Inclusion Criteria Recent-onset AF (≤ 1 year prior to enrolment) At least one ECG within recent 12 months that documents AF whereas … Read more
AXAFA-AFNET 5 Anticoagulation using the direct factor Xa inhibitor apixaban during Atrial Fibrillation catheter Ablation: Comparison to vitamin K antagonist therapy (AXAFA) Study design Investigator-driven, prospective, parallel-group, randomised, open, Blinded Outcome Assessment (PROBE),multi-centre trial to determine the optimal anticoagulation therapy for patients undergoing catheter ablation of atrial fibrillation Inclusion Criteria Non-valvular AF (ECG-documented) with a … Read more
NOAH-AFNET 6 Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High-rate episodes study design Investigator-driven, prospective, parallel-group, randomized, event-driven, double-blind, multicenter phase IIIb trial to evaluate the potential benefit of oral anticoagulation therapy in patients with AHRE, but without overt AF. The trial is to test whether treatment with the newly introduced NOAC edoxaban is superior to … Read more
AXADIA-AFNET 8 Safety Study Assessing Oral Anticoagulation with Apixaban versus Vitamin-K Antagonists in Patients with Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD) on Chronic Hemodialysis Treatment Study design Investigator-initiated, national, open-label, randomised, multicentre, phase IIIb study to evaluate the safety of the new oral anticoagulant apixaban versus the Vitanin-K anatagonist phenprocoumon in the prevention of … Read more
EASThigh-AFNET 11 Early atrial fibrillation Ablation for STroke prevention in patients with high comorbidity burden Study design EASThigh-AFNET 11 is an international, prospective, randomized, open, blinded endpoint assessment, multicenter trial (Treatment Strategy trial). The objective of EASThigh-AFNET 11 is to investigate whether early atrial fibrillation ablation in patients with atrial fibrillation (AF) and a high comorbidity … Read more
