{"id":17970,"date":"2026-09-07T10:05:20","date_gmt":"2026-09-07T10:05:20","guid":{"rendered":"https:\/\/www.af-net.eu\/?page_id=17970"},"modified":"2026-09-09T11:49:50","modified_gmt":"2026-09-09T11:49:50","slug":"caba-mitra-afnet-12-dzhk-34","status":"publish","type":"page","link":"https:\/\/www.af-net.eu\/en\/caba-mitra-afnet-12-dzhk-34\/","title":{"rendered":"CABA-MiTRA-AFNET 12-DZHK 34"},"content":{"rendered":"\n
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\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
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CABA-MiTRA-AFNET 12-DZHK 34<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n

C<\/strong>atheter Ab<\/strong>lation for A<\/strong>F in patients with severe Mitra<\/strong>l Regurgitation after successful Transcatheter Mitral-Valve repair<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Study design<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n

An investigator-initiated, multicenter, prospective, randomized, open-label study with blinded endpoint assessment (PROBE design). This study investigates whether patients with atrial fibrillation are better protected against strokes and other serious complications after successful mitral valve repair through ablation than through standard treatment (Therapy Strategy Trial).<\/p>\n<\/div>\n\n\n\n

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PI Team CABA-MiTRA-AFNET 12-DZHK 34<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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Inclusion Criteria<\/strong><\/h5>\n\n\n\n

\"\" Patienten mit EKG-dokumentiertem Vorhofflimmern<\/p>\n\n\n\n

\"\" Transcatheter edge-to-edge mitral-valve repair (TEER) for severe functional mitral valve regurgitation (MR) with successful result (less than moderate MR, gradient < 5 mmHg) performed within a period of minimum of 30 days and a maximum of 6 months. Moderate residual MR is eligible if no further mitral valve intervention or surgery is planned and patient is stable for > 3 months.<\/p>\n\n\n\n

\"\" Informed, written consent.<\/p>\n<\/div>\n\n\n\n

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Exclusion criteria<\/strong><\/h5>\n\n\n\n

\"\" Age <18 years<\/p>\n\n\n\n

\"\" Patient not suitable for AF ablation<\/p>\n\n\n\n

\"\"Previous ablation procedure for AF<\/p>\n\n\n\n

\"\"Acute coronary syndrome, cardiac surgery, angioplasty, or cerebrovascular accident within 2 months prior to enrolment<\/p>\n\n\n\n

\"\"Untreated hypothyroidism or hyperthyroidism requiring therapy<\/p>\n\n\n\n

\"\"Enrolment in another randomised study<\/p>\n\n\n\n

\"\"Indication for cardiac resynchronization therapy<\/p>\n\n\n\n

\"\"Current pregnancy, breastfeeding, or women not using reliable contraceptive measures during fertility age<\/p>\n\n\n\n

\"\"Mental or physical inability to participate in the study<\/p>\n\n\n\n

\"\"Planned cardiovascular intervention or operation<\/p>\n\n\n\n

\"\"Life expectancy \u2264 12 month<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Research Question \/ Hypothesis<\/strong><\/h2>\n\n\n\n
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Research Question \/<\/strong><\/strong><\/h2>\n\n\n\n

Hypothesis<\/strong><\/strong><\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n

The CABA-MiTRA-AFNET 12-DZHK 34 study (Catheter Ablation for AF in patients with severe mitral regurgitation after successful transcatheter mitral valve repair) is investigating whether catheter ablation for atrial fibrillation in patients following TEER is superior to standard treatment in terms of reducing major adverse cardiovascular and cerebrovascular events (MACCE).<\/p>\n<\/div>\n\n\n\n

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Patients<\/strong><\/strong><\/p>\n\n\n\n

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Approx.<\/p>\n\n\n\n

<\/span>%<\/span><\/div>
<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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<\/h2>\n\n\n\n

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Study sites<\/strong><\/strong><\/p>\n\n\n\n

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Approx.<\/p>\n\n\n\n

<\/span>%<\/span><\/div>
<\/div><\/div>\n<\/div>\n\n\n\n

in Germany and further European Countries, if applicable<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Study duration<\/strong><\/h2>\n\n\n\n
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Study start<\/strong><\/h4>\n\n\n\n

01.09.2026<\/strong><\/p>\n<\/div>\n\n\n\n

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Expected end of study<\/strong><\/strong><\/h4>\n\n\n\n

voraussichtlich 30.09.2032 (endpoint-driven study)<\/strong><\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Study information for download<\/strong><\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n
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\n\tStudy design<\/strong>
\n\t\t\"\"\n\t\t\"\"<\/a>\n<\/div>\n<\/div>\n\n\n\n
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\n\tPocket Card<\/strong>
\n\t\t\"\"\n\t\t\"\"<\/a>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
<\/div>\n\n\n\n
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Publications<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n

Fabritz Larissa, Connolly D., Czarnecki E., Dudek D., Zlahoda-Huzior A., Guasch E., Haase D., Huebner T., Jolly K., Kirchhof P., Schotten Ulrich, Zapf Antonia, Schnabel Renate B: Remote Design of a Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study: Smart in OAC \u2013 AFNET 9<\/strong>. Frontiers in Cardiovascular Medicine, (2022), 9 https:\/\/www.frontiersin.org\/article\/10.3389\/fcvm.2022.839202<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Coordinating Investigators<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n
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\"\"<\/figure>\n<\/div>\n\n\n
Prof. Dr. med. <\/strong>
Lars<\/strong> Eckardt<\/strong><\/h5>\n\n\n\n

Muenster<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
Prof. Dr. med. <\/strong>
Daniel Steven<\/strong><\/h5>\n\n\n\n

Cologne<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n
Prof. Dr. med. <\/strong>
Reza Wakili<\/strong><\/h5>\n\n\n\n

Frankfurt<\/p>\n<\/div>\n\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n
Prof. Dr. med.<\/strong> <\/strong>
Stephan Willems<\/strong><\/h5>\n\n\n\n

Hamburg<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n
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Further Information<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n\n
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Registration<\/h4>\n\n\n\n

ClinicalTrials.gov: NCT07380932<\/p>\n\n\n\n

Support<\/h4>\n\n\n\n

Abbott Medical<\/a><\/p>\n\n\n\n

Biosense Webster\/Johnson & Johnson<\/a><\/p>\n\n\n\n

Boston Scientific<\/a><\/p>\n\n\n\n

Deutsche Herzstiftung<\/a><\/p>\n\n\n\n

Deutsches Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK)<\/a><\/p>\n<\/div>\n\n\n\n

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Sponsor<\/h4>\n\n\n\n

Kompetenznetz Vorhofflimmern e.V. (AFNET), M\u00fcnster<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

CABA-MiTRA-AFNET 12-DZHK 34 Catheter Ablation for AF in patients with severe Mitral Regurgitation after successful Transcatheter Mitral-Valve repair Study design An investigator-initiated, multicenter, prospective, randomized, open-label study with blinded endpoint assessment (PROBE design). This study investigates whether patients with atrial fibrillation are better protected against strokes and other serious complications after successful mitral valve repair … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","iawp_total_views":24,"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":"","_members_access_role":[],"_members_access_error":""},"class_list":["post-17970","page","type-page","status-publish"],"acf":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"timeline-express":false,"timeline-express-thumbnail":false,"1536x1536":false,"2048x2048":false,"vp_sm":false,"vp_md":false,"vp_lg":false,"vp_xl":false,"vp_sm_popup":false,"vp_md_popup":false,"vp_xl_popup":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/www.af-net.eu\/en\/author\/cre8ors\/"},"uagb_comment_info":0,"uagb_excerpt":"CABA-MiTRA-AFNET 12-DZHK 34 Catheter Ablation for AF in patients with severe Mitral Regurgitation after successful Transcatheter Mitral-Valve repair Study design An investigator-initiated, multicenter, prospective, randomized, open-label study with blinded endpoint assessment (PROBE design). This study investigates whether patients with atrial fibrillation are better protected against strokes and other serious complications after successful mitral valve repair…","_links":{"self":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/17970","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/comments?post=17970"}],"version-history":[{"count":13,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/17970\/revisions"}],"predecessor-version":[{"id":18029,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/17970\/revisions\/18029"}],"wp:attachment":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/media?parent=17970"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}