{"id":13754,"date":"2025-03-05T12:16:28","date_gmt":"2025-03-05T12:16:28","guid":{"rendered":"https:\/\/af-net.eu\/?page_id=13754"},"modified":"2026-02-18T10:43:30","modified_gmt":"2026-02-18T10:43:30","slug":"partnerstudie-east-stroke","status":"publish","type":"page","link":"https:\/\/www.af-net.eu\/en\/partnerstudie-east-stroke\/","title":{"rendered":"Partnerstudie – EAST-STROKE"},"content":{"rendered":"\n
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EAST-STROKE<\/strong><\/h2>\n\n\n\n
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Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE)<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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STUDY DESIGN<\/strong><\/h2>\n\n\n\n
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EAST-STROKE is an international, investigator-initiated, prospective, randomised, open-label study with blinded outcome assessment (PROBE design).<\/p>\n<\/div>\n\n\n\n

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Hypothesis<\/strong><\/h5>\n\n\n\n

The EAST-STROKE study is investigating whether early rhythm control can prevent the occurrence of cardiovascular events in patients with atrial fibrillation and acute ischaemic stroke compared to standard treatment.<\/p>\n<\/div>\n\n\n\n

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Description<\/strong><\/h5>\n\n\n\n

Atrial fibrillation is one of the most common causes of ischaemic stroke. Stroke patients with atrial fibrillation have a high risk of a recurrent cardiovascular event. The current treatment of atrial fibrillation after an acute stroke usually involves oral anticoagulation, rate control and adjustment of cardiovascular risk factors, but no systematic rhythm control. The EAST-AFNET 4 study has already demonstrated the benefit of early rhythm maintenance therapy in patients with atrial fibrillation. In addition, a subgroup analysis showed that early rhythm control also has a particularly high benefit in patients with a history of stroke. <\/p>\n<\/div>\n\n\n\n

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The EAST-STROKE study is therefore investigating whether early rhythm control can also prevent the occurrence of cardiovascular events in patients with atrial fibrillation and an acute ischaemic stroke compared to standard treatment.

EAST-STROKE is an international, investigator-initiated, prospective, randomised, open-label study with blinded outcome assessment (PROBE design). The study is funded by the EU with \u2018Horizon Europe\u2019 and will initially start in 42 clinics in Germany, Spain, Switzerland and the Netherlands; the participation of other countries is planned in the course of the study. A total of 1,746 patients are to be included in the study.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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CONTACT INFORMATION<\/strong><\/h2>\n\n\n\n
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Prof Ulf Landmesser, MD<\/strong><\/h5>\n\n\n\n

Principal Investigator<\/p>\n\n\n\n

Klinik und Poliklinik f\u00fcr Neurologie, Universit\u00e4tsklinikum Hamburg-Eppendorf<\/p>\n<\/div>\n\n\n\n

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Prof Paulus Kirchhof, MD<\/strong><\/h5>\n\n\n\n

Principal Investigator<\/p>\n\n\n\n

Klinik und Poliklinik f\u00fcr Kardiologie, Universit\u00e4tsklinikum Hamburg-Eppendorf<\/p>\n<\/div>\n\n\n\n

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Dr. med. M\u00e4rit Jensen<\/strong><\/h5>\n\n\n\n

Principal Co-Investigator and study coordinator<\/p>\n\n\n\n

Klinik und Poliklinik f\u00fcr Neurologie, Universit\u00e4tsklinikum Hamburg-Eppendorf<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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FURTHER INFORMATION<\/strong><\/h2>\n\n\n\n
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Homepage<\/h4>\n\n\n\n

east-stroke.de<\/a><\/p>\n\n\n\n

SPONSOR<\/h4>\n\n\n\n

Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)<\/p>\n\n\n\n

FUNDING<\/h4>\n\n\n\n

Funded by the European Union. Grant Agreement No 101156541 \u2014 EAST-STROKE<\/p>\n<\/div>\n\n\n\n

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AFNET ROLE<\/h4>\n\n\n\n

Partner, responsible for the work packages dissemination and communication<\/p>\n\n\n\n

Videointerviews<\/h4>\n\n\n\n

Interview with G\u00f6tz Thomalla and M\u00e4rit Jensen<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

EAST-STROKE Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE) STUDY DESIGN EAST-STROKE is an international, investigator-initiated, prospective, randomised, open-label study with blinded outcome assessment (PROBE design). Hypothesis The EAST-STROKE study is investigating whether early rhythm control can prevent the occurrence of cardiovascular events in patients with atrial fibrillation and acute … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","iawp_total_views":41,"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"class_list":["post-13754","page","type-page","status-publish"],"acf":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"timeline-express":false,"timeline-express-thumbnail":false,"1536x1536":false,"2048x2048":false,"vp_sm":false,"vp_md":false,"vp_lg":false,"vp_xl":false,"vp_sm_popup":false,"vp_md_popup":false,"vp_xl_popup":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/www.af-net.eu\/en\/author\/cre8ors\/"},"uagb_comment_info":0,"uagb_excerpt":"EAST-STROKE Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE) STUDY DESIGN EAST-STROKE is an international, investigator-initiated, prospective, randomised, open-label study with blinded outcome assessment (PROBE design). Hypothesis The EAST-STROKE study is investigating whether early rhythm control can prevent the occurrence of cardiovascular events in patients with atrial fibrillation and acute…","_links":{"self":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/comments?post=13754"}],"version-history":[{"count":14,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13754\/revisions"}],"predecessor-version":[{"id":16370,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13754\/revisions\/16370"}],"wp:attachment":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/media?parent=13754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}