{"id":13749,"date":"2025-03-05T12:16:13","date_gmt":"2025-03-05T12:16:13","guid":{"rendered":"https:\/\/af-net.eu\/?page_id=13749"},"modified":"2026-05-11T11:30:46","modified_gmt":"2026-05-11T11:30:46","slug":"partnerstudie-closure-af-dzhk16","status":"publish","type":"page","link":"https:\/\/www.af-net.eu\/en\/partnerstudie-closure-af-dzhk16\/","title":{"rendered":"Partnerstudie – CLOSURE-AF-DZHK16"},"content":{"rendered":"\n
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CLOSURE-AF-DZHK16<\/strong><\/h2>\n\n\n\n
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Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy: a prospective randomized clinical trial<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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Ingo EiteL: Interventional stroke prevention in AF<\/em><\/strong><\/strong><\/strong><\/h2>\n\n\n\n
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You are currently viewing a placeholder content from YouTube<\/strong>. To access the actual content, click the button below. Please note that doing so will share data with third-party providers.<\/p> More Information<\/a> <\/div>

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STUDY DESIGN<\/strong><\/strong><\/h2>\n\n\n\n
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Prospective, multi-centre, national, unblinded, randomized study.<\/p>\n<\/div>\n\n\n\n

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Study objective<\/strong><\/strong><\/h5>\n\n\n\n

Study goal is to determine the clinical benefit of a strategy of percutaneous catheter\u2010based left atrial appendage (LAA) closure in patients with non-valvular atrial fibrillation (NVAF) at high risk of stroke (CHA2DS2\u2010VASc Score \u22652) and bleeding as compared to best medical care.<\/p>\n<\/div>\n\n\n\n

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Description<\/strong><\/strong><\/h5>\n\n\n\n

Atrial fibrillation is the most common cardiac arrhythmia in Germany. With atrial fibrillation, there is a risk of clots forming in the heart, particularly in the left atrial appendage), a part of the heart. If these clots come loose, there is a risk of stroke. To prevent strokes, patients with atrial fibrillation can be given medication known as anticoagulants. These drugs prevent the formation of clots in the heart.<\/p>\n<\/div>\n\n\n\n

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Another treatment option is to close the left atrial appendage with a closure system (occluder), which prevents clots from reaching the brain or the body. After the left atrial appendage has been closed, the blood only needs to be diluted for a short time until the occluder has healed. The CLOSURE-AF study compares the two clinically established treatment approaches (blood thinning with medication and closure of the left heart ear using a catheter technique). Only approved anticoagulants and closure systems will be used.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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CONTACT INFORMATION<\/strong><\/strong><\/h2>\n\n\n\n
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Prof. Dr. med. Ulf Landmesser<\/strong><\/h5>\n\n\n\n

Director of Studies<\/p>\n\n\n\n

Charit\u00e9 – Universit\u00e4tsmedizin Berlin<\/p>\n<\/div>\n\n\n\n

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Prof. Dr. med. Ingo Eitel<\/strong><\/h5>\n\n\n\n

Co-study director<\/p>\n\n\n\n

Medizinische Klinik II, Universit\u00e4res Herzzentrum L\u00fcbeck
Universit\u00e4tsklinikum Schleswig-Holstein<\/p>\n<\/div>\n\n\n\n

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Prof. Dr. med. Leif-Hendrick Boldt<\/strong><\/h5>\n\n\n\n

Co-study director<\/p>\n\n\n\n

Medizinische Klinik mit Schwerpunkt Kardiologie 
Charit\u00e9 – Universit\u00e4tsmedizin Berlin<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

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FURTHER INFORMATION<\/strong><\/strong><\/h2>\n\n\n\n
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Homepage<\/h4>\n\n\n\n

closure-af.dzhk.de<\/a><\/p>\n\n\n\n

SPONSOR<\/h4>\n\n\n\n

Charit\u00e9 – Universit\u00e4tsmedizin Berlin<\/p>\n<\/div>\n\n\n\n

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AFNET ROLE<\/h4>\n\n\n\n

Regulatory Project Management, organisation and support of committees (CEC) and meetings, support of the study coordinator with e.g. supervision of sites<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

CLOSURE-AF-DZHK16 Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy: a prospective randomized clinical trial Ingo EiteL: Interventional stroke prevention in AF STUDY DESIGN Prospective, multi-centre, national, unblinded, randomized study. Study objective Study goal is to determine the clinical benefit of a strategy of … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","iawp_total_views":42,"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"class_list":["post-13749","page","type-page","status-publish"],"acf":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"timeline-express":false,"timeline-express-thumbnail":false,"1536x1536":false,"2048x2048":false,"vp_sm":false,"vp_md":false,"vp_lg":false,"vp_xl":false,"vp_sm_popup":false,"vp_md_popup":false,"vp_xl_popup":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/www.af-net.eu\/en\/author\/cre8ors\/"},"uagb_comment_info":0,"uagb_excerpt":"CLOSURE-AF-DZHK16 Left atrial appendage CLOSURE in patients with Atrial Fibrillation at high risk of stroke and bleeding compared to medical therapy: a prospective randomized clinical trial Ingo EiteL: Interventional stroke prevention in AF STUDY DESIGN Prospective, multi-centre, national, unblinded, randomized study. Study objective Study goal is to determine the clinical benefit of a strategy of…","_links":{"self":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/comments?post=13749"}],"version-history":[{"count":15,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13749\/revisions"}],"predecessor-version":[{"id":17222,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/13749\/revisions\/17222"}],"wp:attachment":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/media?parent=13749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}