{"id":11375,"date":"2024-08-14T11:08:09","date_gmt":"2024-08-14T11:08:09","guid":{"rendered":"https:\/\/www.friendly-bartik.94-130-216-58.plesk.page\/east\/"},"modified":"2024-12-16T13:19:27","modified_gmt":"2024-12-16T13:19:27","slug":"east","status":"publish","type":"page","link":"https:\/\/www.af-net.eu\/en\/east\/","title":{"rendered":"EAST"},"content":{"rendered":"\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/07\/east_600x600px.jpg\" alt=\"\" class=\"wp-image-710\" style=\"width:337px\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/07\/east_600x600px.jpg 600w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/07\/east_600x600px-300x300.jpg 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/07\/east_600x600px-150x150.jpg 150w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-a01860a1cef596d4ff520e8967a5b6bf\" style=\"text-transform:uppercase\"><strong>EAST<\/strong>-AFNET 4<\/h2>\n\n\n\n<div class=\"east\"> <\/div>\n\n\n\n<p>Early treatment of&nbsp;atrial fibrillation for&nbsp;stroke prevention&nbsp;trial (EAST)<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" id=\"abstand-weg\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-background\" id=\"studiendesign-block-hacken\" style=\"background-color:#dde9f2\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-e3f116900fb9f16b458a8223d2874122\" style=\"text-transform:uppercase\"><strong>study design<\/strong><\/h2>\n\n\n\n<div class=\"studydesign-dotted\"> <\/div>\n\n\n\n<p>Investigator-driven, prospective, parallel-group, randomised, open-label trial with blinded-outcome assessment (PROBE-Design). Multi-centre trial for Prevention of Stroke in High-risk Subjects with Atrial Fibillation<br><br><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"video-studien-margin-top-less\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-1024x683.jpg\" alt=\"\" class=\"wp-image-6495\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-1024x683.jpg 1024w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-300x200.jpg 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-768x513.jpg 768w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-1536x1025.jpg 1536w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-2048x1367.jpg 2048w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-500x334.jpg 500w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-800x534.jpg 800w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-1280x854.jpg 1280w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/10\/signing-business-document-1920x1281.jpg 1920w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"positiv-zeichen\">\n<h5 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-05744b5ae8840d59b857e20d2455e3d7\"><strong>Inclusion Criteria<\/strong><\/h5>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> Recent-onset AF (\u2264 1 year prior to enrolment)<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> At least one ECG within recent 12 months that documents AF whereas the AF episode must last longer than 30 sec.<\/p>\n\n\n\n<p>One of the following:<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> age &gt; 75 years or<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> prior stroke or transient ischemic attack<\/p>\n\n\n\n<p>OR two of the following:<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> age &gt; 65 years,<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> female sex,<\/p>\n\n\n\n<div class=\"wp-block-uagb-tabs uagb-block-54dc661b uagb-tabs__wrap uagb-tabs__hstyle2-desktop uagb-tabs__vstyle6-tablet uagb-tabs__stack1-mobile\" data-tab-active=\"0\"><ul class=\"uagb-tabs__panel uagb-tabs__align-left\" role=\"tablist\"><li class=\"uagb-tab uagb-tabs__active\" role=\"none\"><a href=\"#uagb-tabs__tab0\" class=\"uagb-tabs-list uagb-tabs__icon-position-left\" data-tab=\"0\" role=\"tab\"><div>Show more ><\/div><\/a><\/li><\/ul><div class=\"uagb-tabs__body-wrap\">\n<div class=\"wp-block-uagb-tabs-child uagb-tabs__body-container uagb-inner-tab-0\" aria-labelledby=\"uagb-tabs__tab0\">\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> arterial hypertension (chronic treatment for hypertension, estimated need for continuous antihypertensive therapy or resting blood pressure &gt; 145\/90 mmHg),<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> diabetes mellitus (treated by drugs or insulin) or impaired glucose tolerance<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> severe coronary artery disease (previous myocardial infarction, CABG or PCI)<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> stable heart failure (NYHA II or LVEF &lt;50%),<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> left ventricular hypertrophy on echocardiography (more than 15 mm wall thickness),<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> chronic kidney disease (MDRD stage III or IV),<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> peripheral artery disease.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> Provision of signed informed consent.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"17\" height=\"30\" class=\"wp-image-2570\" style=\"width: 17px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2713.png\" alt=\"\"> Age \u2265 18 years.<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" id=\"negativ-zeichen\">\n<h5 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-274e1faad96ce9da20eac2bda2c5b77f\"><strong>Exclusion Criteria<\/strong><\/h5>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Any disease that limits life expectancy to less than 1 year.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Participation in another clinical trial, either within the past two months or ongoing<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Previous participation in the EAST trial.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Pregnant women or women of childbearing potential not on adequate birth control: only women with a highly effective method of contraception [oral contraception or intra-uterine device (IUD)] or sterile women can be randomized.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Breastfeeding women.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Drug abuse.<\/p>\n\n\n\n<div class=\"wp-block-uagb-tabs uagb-block-051aa890 uagb-tabs__wrap uagb-tabs__hstyle2-desktop uagb-tabs__vstyle6-tablet uagb-tabs__stack1-mobile\" data-tab-active=\"0\"><ul class=\"uagb-tabs__panel uagb-tabs__align-left\" role=\"tablist\"><li class=\"uagb-tab uagb-tabs__active\" role=\"none\"><a href=\"#uagb-tabs__tab0\" class=\"uagb-tabs-list uagb-tabs__icon-position-left\" data-tab=\"0\" role=\"tab\"><div>Show more ><\/div><\/a><\/li><\/ul><div class=\"uagb-tabs__body-wrap\">\n<div class=\"wp-block-uagb-tabs-child uagb-tabs__body-container uagb-inner-tab-0\" aria-labelledby=\"uagb-tabs__tab0\">\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Prior AF ablation or surgical therapy of AF.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Previous therapy failure on amiodarone, e.g. patients who suffered from symptomatic recurrent AF that required escalation of therapy while on amiodarone.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\"> Patients not suitable for rhythm control of AF.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\">Severe mitral valve stenosis.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\">Prosthetic<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\">Clinically relevant hepatic dysfunction requiring specific therapy.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\">Clinically manifest thyroid dysfunction requiring therapy. After successful treatment of thyroid dysfunction, patients may be enrolled when their thyroid function is controlled.<\/p>\n\n\n\n<p><img loading=\"lazy\" decoding=\"async\" width=\"19\" height=\"30\" class=\"wp-image-2571\" style=\"width: 19px;\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/\u2717.png\" alt=\"\">Severe renal dysfunction (stage V, requiring or almost requiring dialysis).<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-b0997938a1603e9b53dd0a406c1902b0\" style=\"text-transform:uppercase\"><strong><strong>hypothesis<\/strong><\/strong><\/h2>\n\n\n\n<div class=\"research-dotted\"> <\/div>\n\n\n\n<p>Early, structured rhythm control therapy based on antiarrhythmic drugs and catheter ablation can prevent atrial fibrillation (AF) related complications in patients with AF when compared to usual care.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-80931c02f799cf7f592c4cdbd6413e95\" style=\"text-transform:uppercase\"><strong>Conclusion <\/strong><\/h2>\n\n\n\n<div class=\"conclusion-dotted\"> <\/div>\n\n\n\n<p>The effectiveness of early rhythm control is mediated by the presence of sinus rhythm at 12 months in the EAST-AFNET 4 trial. Clinicians implementing ERC should aim for rapid and sustained restoration of sinus rhythm in patients with recently diagnosed AF and cardiovascular comorbidities.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-d16ff33e747c1d739410773a294221e5\" id=\"counter-p\" style=\"text-transform:uppercase\"><strong><strong>PATIENTS<\/strong><\/strong><\/p>\n\n\n\n<div data-aos= \"zoom-in-down\" data-aos-duration=\"400\" data-aos-delay=\"0\" data-aos-easing=\"ease\" data-aos-once=\"true\" class=\"wp-block-uagb-counter uagb-block-9ecbea7b wp-block-uagb-counter--number\" id=\"Studienzahlen\"><div class=\"wp-block-uagb-counter__number\"><span class=\"uagb-counter-block-number\" data-duration=\"1.5\" data-to-value=\"2789\" data-from-value=\"0\" data-delimiter=\",\"><\/span><span class=\"uagb-counter-block-suffix\">%<\/span><\/div><div class=\"wp-block-uagb-counter__title\"><\/div><\/div>\n\n\n\n<div class=\"underline-dotted-h-counter\"> <\/div>\n\n\n\n<p class=\"has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-bfff55bfbbd4e53f76c995b4fb49ce1d\" id=\"counter-p\" style=\"text-transform:uppercase\"><strong><strong>STUDY CENTRES<\/strong><br>in 11 European countries<\/strong><\/p>\n\n\n\n<div data-aos= \"zoom-in-down\" data-aos-duration=\"400\" data-aos-delay=\"0\" data-aos-easing=\"ease\" data-aos-once=\"true\" class=\"wp-block-uagb-counter uagb-block-d59caaa1 wp-block-uagb-counter--number\" id=\"Studienzahlen\"><div class=\"wp-block-uagb-counter__number\"><span class=\"uagb-counter-block-number\" data-duration=\"1.5\" data-to-value=\"135\" data-from-value=\"0\" data-delimiter=\",\"><\/span><span class=\"uagb-counter-block-suffix\">%<\/span><\/div><div class=\"wp-block-uagb-counter__title\"><\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" id=\"abstand-weg\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-1e42701984e04243472f271b70ee0c13\" style=\"text-transform:uppercase\"><strong>Study duration<\/strong><\/h2>\n\n\n\n<div class=\"studyprocedure-dotted\"> <\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-hell-blue-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" id=\"ablauf-schraeg\">\n<h4 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-62cf9e3f7a132b8949978e3c39eca236\"><strong>Start of study<\/strong><\/h4>\n\n\n\n<p class=\"has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-61a39944dc47bbf33ef462c1baa0b882\"><strong>2011<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-afnet-gelb-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" id=\"ablauf-schraeg\">\n<h4 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-d07215e91f93b15784880aed59c568a6\"><strong>End of study<\/strong><\/h4>\n\n\n\n<p class=\"has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-ccfc7b9e585dd0e5beb29dd1800c4551\"><strong>2020<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" id=\"abstand-weg\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-4bf7a5ff3d027fc2d7c6703dc24b14df\" style=\"text-transform:uppercase\"><strong>Study information for download<\/strong><\/h2>\n\n\n\n<div class=\"studyinformation-dotted\"> <\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"button-unterseiten-hover\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"btn_mitdesign\">\n\t<a download=\"\" href=\"\/wp-content\/uploads\/2024\/11\/EAST-study-design.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Study design<\/strong><br>\n\t\t<img decoding=\"async\" class=\"blue-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-blau.svg\" alt=\"\">\n\t\t<img decoding=\"async\" class=\"white-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-weiss.svg\" alt=\"\"><\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"btn_mitdesign\">\n\t<a download=\"\" href=\"\/wp-content\/uploads\/2024\/11\/EAST-main-result.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Main result<\/strong><br>\n\t\t<img decoding=\"async\" class=\"blue-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-blau.svg\" alt=\"\">\n\t\t<img decoding=\"async\" class=\"white-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-weiss.svg\" alt=\"\"><\/a>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"btn_mitdesign\">\n\t<a download=\"\" href=\"\/wp-content\/uploads\/2024\/11\/EAST-subanalyses.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Subanalyses<\/strong><br>\n\t\t<img decoding=\"async\" class=\"blue-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-blau.svg\" alt=\"\">\n\t\t<img decoding=\"async\" class=\"white-download\" style=\"width: 30px;\" src=\"\/wp-content\/uploads\/2024\/07\/Download-icon-weiss.svg\" alt=\"\"><\/a>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" id=\"abstand-weg\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-e98d9d0b2cc4d4920d858a6ae85d9a92\" style=\"text-transform:uppercase\"><strong>Publications<\/strong><\/h2>\n\n\n\n<div class=\"publications-dotted\"> <\/div>\n\n\n\n<p class=\"has-afnet-blau-color has-text-color has-background has-link-color wp-elements-79bfddfb226b5db1bef7c913b76173de\" style=\"background-color:#dde9f2\">Aliot E, Brandes A, Eckardt L, Elvan A, Gulizia M, Heidbuchel H, Kautzner J, Mont L, Morgan J, Ng A, Szumowski L, Themistoclakis S, Van Gelder IC, Willems S, Kirchhof P. <strong>The EAST study: redefining the role of rhythmcontrol therapy in atrial fibrillation: EAST, the Early treatment of Atrial fibrillation for Stroke prevention Trial. Eur Heart J.<\/strong> 2015 Feb 1;36(5):255-6. doi: 10.1093\/eurheartj\/ehu476. PMID: 25646394.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-uagb-tabs uagb-block-d9eecc0f uagb-tabs__wrap uagb-tabs__hstyle2-desktop uagb-tabs__vstyle6-tablet uagb-tabs__stack1-mobile\" data-tab-active=\"0\" id=\"mehr-anzeigen-studien\"><ul class=\"uagb-tabs__panel uagb-tabs__align-center\" role=\"tablist\"><li class=\"uagb-tab uagb-tabs__active\" role=\"none\"><a href=\"#uagb-tabs__tab0\" class=\"uagb-tabs-list uagb-tabs__icon-position-left\" data-tab=\"0\" role=\"tab\"><span class=\"uagb-tabs__icon\"><svg xmlns=\"https:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 384 512\"><path d=\"M374.6 310.6l-160 160C208.4 476.9 200.2 480 192 480s-16.38-3.125-22.62-9.375l-160-160c-12.5-12.5-12.5-32.75 0-45.25s32.75-12.5 45.25 0L160 370.8V64c0-17.69 14.33-31.1 31.1-31.1S224 46.31 224 64v306.8l105.4-105.4c12.5-12.5 32.75-12.5 45.25 0S387.1 298.1 374.6 310.6z\"><\/path><\/svg><\/span><div>Show more<\/div><\/a><\/li><\/ul><div class=\"uagb-tabs__body-wrap\">\n<div class=\"wp-block-uagb-tabs-child uagb-tabs__body-container uagb-inner-tab-0\" aria-labelledby=\"uagb-tabs__tab0\" id=\"mehr-anzeigen-studien\">\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-892c3f86833a4bd7d050cdd22cd81fcf\" style=\"background-color:#dde9f2\">Eckardt L, Sehner S, Suling A, Borof K, Breithardt G, Crijns H, Goette A, Wegscheider K, Zapf A, Camm J, Metzner A, Kirchhof P. <strong>Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST-AFNET 4 trial. Eur Heart J.<\/strong> 2022 Oct 21;43(40):4127-4144. doi: 10.1093\/eurheartj\/ehac471. PMID: 36036648; PMCID: PMC9584752.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-de04e3a17805f138e46cd9e06e47f3e5\" style=\"background-color:#dde9f2\">Fabritz L, Al-Taie C, Borof K, Breithardt G, Camm AJ, Crijns HJGM, Roth Cardoso V, Chua W, van Elferen S, Eckardt L, Gkoutos G, Goette A, Guasch E, Hatem S, Metzner A, Mont L, Murukutla VA, Obergassel J, Rillig A, Sinner MF, Schnabel RB, Schotten U, Sommerfeld LC, Wienhues-Thelen UH, Zapf A, Zeller T, Kirchhof P. <strong>Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study. Eur Heart J.<\/strong> 2024 Aug 31:ehae611. doi: 10.1093\/eurheartj\/ehae611. Epub ahead of print. PMID: 39215973.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-da282c88353467463928b1ac29908582\" style=\"background-color:#dde9f2\">Fabritz L, Chua W, Cardoso VR, Al-Taie C, Borof K, Suling A, Krause L, Kany S, Magnussen C, Wegscheider K, Breithardt G, Crijns HJGM, Camm AJ, Gkoutos G, Ellinor PT, Goette A, Schotten U, Wienhues-Thelen UH, Zeller T, Schnabel RB, Zapf A, Kirchhof P. <strong>Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study.<\/strong> <strong>Cardiovasc Res.<\/strong> 2024 Jul 2;120(8):855-868. doi: 10.1093\/cvr\/cvae067. PMID: 38613511; PMCID: PMC11218688.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-9c1aab169fc9f9024dbe895b3391947c\" style=\"background-color:#dde9f2\">Goette A, Borof K, Breithardt G, Camm AJ, Crijns HJGM, Kuck KH, Wegscheider K, Kirchhof P; <strong>EAST-AFNET 4 Investigators. Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control&nbsp;Therapy. J Am Coll Cardiol.<\/strong> 2022 Jul 26;80(4):283-295. doi: 10.1016\/j.jacc.2022.04.058. PMID: 35863844.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-e48bec267f0603c51bf771937dee38a7\" style=\"background-color:#dde9f2\">Gottschalk S, Kany S, K\u00f6nig HH, Crijns HJ, Vardas P, Camm AJ, Wegscheider K, Metzner A, Rillig A, Kirchhof P, Dams J. <strong>Cost-effectiveness of early rhythm control vs. usual care in atrial fibrillation care: an analysis based on data from the EAST-AFNET 4 trial. Europace.<\/strong> 2023 May 19;25(5):euad051. doi: 10.1093\/europace\/euad051. PMID: 36966734; PMCID: PMC10227663.<\/p>\n\n\n\n<p class=\"has-afnet-blau-color has-text-color has-background has-link-color wp-elements-1ebf022ba902336cd1a82195daa1495f\" style=\"background-color:#dde9f2\">Jensen M, Suling A, Metzner A, Schnabel RB, Borof K, Goette A, Haeusler KG, Zapf A, Wegscheider K, Fabritz L, Diener HC, Thomalla G, Kirchhof P. <strong>Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial. Lancet Neurol.<\/strong> 2023 Jan;22(1):45-54. doi: 10.1016\/S1474-4422(22)00436-7. PMID: 36517170.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-5edf9d51c395250d98cda0918cf0de54\" style=\"background-color:#dde9f2\">Kany S, Al-Taie C, Roselli C, Pirruccello JP, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel RB, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor PT, Kirchhof P. <strong>Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial. Cardiovasc Res.<\/strong> 2023 Aug 7;119(9):1799-1810. doi: 10.1093\/cvr\/cvad027. PMID: 37264683; PMCID: PMC10405565.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-c4c3ba5567596eebaae63736eb9be01c\" style=\"background-color:#dde9f2\">Kirchhof P, Wegscheider K, Breithardt G.<strong> Early Rhythm Control in Atrial Fibrillation. Reply. N Engl J Med.<\/strong> 2021 Feb 4;384(5):484-485. doi: 10.1056\/NEJMc2032433. PMID: 33534984.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-018b19a736fef3506051f5f58dfe71e9\" style=\"background-color:#dde9f2\">Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder IC, Haase D, Haegeli LM, Hamann F, Heidb\u00fcchel H, Hindricks G, Kautzner J, Kuck KH, Mont L, Ng GA, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns HJGM, Breithardt G; <strong>EAST-AFNET 4 Trial Investigators. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med.<\/strong> 2020 Oct 1;383(14):1305-1316. doi: 10.1056\/NEJMoa2019422. Epub 2020 Aug 29. PMID: 32865375.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-4af85f7c1e95cf72daad7888db5d79bb\" style=\"background-color:#dde9f2\">Kirchhof P, Breithardt G, Camm AJ, Crijns HJ, Kuck KH, Vardas P, Wegscheider K. <strong>Improving outcomes in patients with atrial fibrillation: rationale and design of the Early treatment of Atrial fibrillation for Stroke prevention Trial. Am Heart J.<\/strong> 2013 Sep;166(3):442-8. doi: 10.1016\/j.ahj.2013.05.015. Epub 2013 Jul 30. PMID: 24016492.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-fdadc5aa3c19ebf3dd07f8f406230433\" style=\"background-color:#dde9f2\">Metzner A, Suling A, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Elvan A, Goette A, Haegeli LM, Heidbuchel H, Kautzner J, Kuck KH, Mont L, Ng GA, Szumowski L, Themistoclakis S, van Gelder IC, Vardas P, Wegscheider K, Willems S, Kirchhof P. <strong>Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST &#8211; AFNET 4 trial. Europace.<\/strong> 2022 Apr 5;24(4):552-564. doi: 10.1093\/europace\/euab200. Erratum in: Europace. 2022 Apr 5;24(4):564. doi: 10.1093\/europace\/euab277. PMID: 34473249; PMCID: PMC8982435.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-f2399f041c45059a432a195426f337f4\" style=\"background-color:#dde9f2\">Rillig A, Eckardt L, Borof K, Camm AJ, Crijns HJGM, Goette A, Breithardt G, Lemoine MD, Metzner A, Rottner L, Schotten U, Vettorazzi E, Wegscheider K, Zapf A, Heidbuchel H, Willems S, Fabritz L, Schnabel RB, Magnussen C, Kirchhof P. <strong>Safety and efficacy of long-term sodium channel blocker therapy for early rhythm control: the EAST-AFNET 4 trial. Europace.<\/strong> 2024 Jun 3;26(6):euae121. doi: 10.1093\/europace\/euae121. PMID: 38702961; PMCID: PMC11154137.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-342a410908e21762a05470c12969e8ef\" style=\"background-color:#dde9f2\">Rillig A, Magnussen C, Ozga AK, Suling A, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Elvan A, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Kuck KH, Ng A, Szumowski L, van Gelder I, Wegscheider K, Kirchhof P. <strong>Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure. Circulation.<\/strong> 2021 Sep 14;144(11):845-858. doi: 10.1161\/CIRCULATIONAHA.121.056323. Epub 2021 Jul 30. PMID: 34328366; PMCID: PMC8456351.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-c48428c5eb6f42bc190f20fad80d256d\" style=\"background-color:#dde9f2\">Rillig A, Borof K, Breithardt G, Camm AJ, Crijns HJGM, Goette A, Kuck KH, Metzner A, Vardas P, Vettorazzi E, Wegscheider K, Zapf A, Kirchhof P. <strong>Early Rhythm Control in Patients With Atrial Fibrillation and High Comorbidity Burden. Circulation.<\/strong> 2022 Sep 13;146(11):836-847. doi: 10.1161\/CIRCULATIONAHA.122.060274. Epub 2022 Aug 15. PMID: 35968706.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-9d98ef79653d3e46a674a29312d1deea\" style=\"background-color:#dde9f2\">Van Gelder IC, Ekrami NK, Borof K, Fetsch T, Magnussen C, Mulder BA, Schnabel R, Wegscheider K, Rienstra M, Kirchhof P; <strong>EAST-AFNET 4<\/strong> <strong>Trial Investigators. Sex Differences in Early Rhythm Control of Atrial Fibrillation in the EAST-AFNET 4 Trial. J Am Coll Cardiol.<\/strong> 2023 Feb 28;81(8):845-847. doi: 10.1016\/j.jacc.2022.12.011. PMID: 36813380.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-85641e77265911b52fc7f6b395c131d9\" style=\"background-color:#dde9f2\">Willems S, Borof K, Brandes A, Breithardt G, Camm AJ, Crijns HJGM, Eckardt L, Gessler N, Goette A, Haegeli LM, Heidbuchel H, Kautzner J, Ng GA, Schnabel RB, Suling A, Szumowski L, Themistoclakis S, Vardas P, van Gelder IC, Wegscheider K, Kirchhof P. <strong>Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. Eur Heart J.<\/strong> 2022 Mar 21;43(12):1219-1230. doi: 10.1093\/eurheartj\/ehab593. PMID: 34447995; PMCID: PMC8934687.<\/p>\n\n\n\n<p class=\"has-text-align-left has-afnet-blau-color has-text-color has-background has-link-color wp-elements-855eadfbb13b17c74b585ab71c258fed\" style=\"background-color:#dde9f2\">Van Gelder IC, Haegeli LM, Brandes A, Heidbuchel H, Aliot E, Kautzner J, Szumowski L, Mont L, Morgan J, Willems S, Themistoclakis S, Gulizia M, Elvan A, Smit MD, Kirchhof P. <strong>Rationale and current perspective for early rhythm control therapy in atrial fibrillation. Europace.<\/strong> 2011 Nov;13(11):1517-25. doi: 10.1093\/europace\/eur192. Epub 2011 Jul 22. PMID: 21784740; PMCID: PMC3198586.<\/p>\n<\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" id=\"abstand-weg\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-background\" id=\"studiendesign-block-hacken\" style=\"background-color:#dde9f2\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-4b5baf5691f2d8dff278d58b7b15340c\" style=\"text-transform:uppercase\"><strong>Scientific Leader<\/strong><\/h2>\n\n\n\n<div class=\"leader-dotted\"> <\/div>\n\n\n\n<div class=\"wp-block-columns has-background is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"Leitungen\" style=\"background-color:#dde9f2\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\" id=\"kreis\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"520\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Vorstand-kreis-Kirchhof-Paulus.png\" alt=\"\" class=\"wp-image-1682\" style=\"object-fit:cover\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Vorstand-kreis-Kirchhof-Paulus.png 520w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Vorstand-kreis-Kirchhof-Paulus-300x300.png 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Vorstand-kreis-Kirchhof-Paulus-150x150.png 150w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Vorstand-kreis-Kirchhof-Paulus-500x500.png 500w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/figure>\n<\/div>\n\n\n<h5 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-9bb0d2e762b86614436cb3aa7909a967\"><strong>Prof. Paulus Kirchhof<\/strong><\/h5>\n\n\n\n<p class=\"has-text-align-center\">Hamburg<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\" id=\"kreis\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"520\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Lenkungsausschuss-kreis-Breithardt.png\" alt=\"\" class=\"wp-image-1688\" style=\"object-fit:cover\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Lenkungsausschuss-kreis-Breithardt.png 520w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Lenkungsausschuss-kreis-Breithardt-300x300.png 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Lenkungsausschuss-kreis-Breithardt-150x150.png 150w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/08\/afnet-Lenkungsausschuss-kreis-Breithardt-500x500.png 500w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/figure>\n<\/div>\n\n\n<h5 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-e4d4cea561433a5ce825e67528d4ae07\"><strong>Prof. G\u00fcnter Breithardt<\/strong><\/h5>\n\n\n\n<p class=\"has-text-align-center\">&nbsp;M\u00fcnster<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\" id=\"kreis\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"520\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Paltzhalter-man-1.png\" alt=\"\" class=\"wp-image-7352\" style=\"object-fit:cover\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Paltzhalter-man-1.png 520w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Paltzhalter-man-1-300x300.png 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Paltzhalter-man-1-150x150.png 150w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Paltzhalter-man-1-500x500.png 500w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/figure>\n<\/div>\n\n\n<h5 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-7672bfaced1e6a1ca6a60ec8edf1976e\"><strong>Prof. <\/strong><strong>Harry Crijns<\/strong><\/h5>\n\n\n\n<p class=\"has-text-align-center\">Maastricht<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\" id=\"kreis\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"520\" src=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Camm_bearb.png\" alt=\"\" class=\"wp-image-8689\" style=\"object-fit:cover\" srcset=\"https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Camm_bearb.png 520w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Camm_bearb-300x300.png 300w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Camm_bearb-150x150.png 150w, https:\/\/www.af-net.eu\/wp-content\/uploads\/2024\/11\/Camm_bearb-500x500.png 500w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/figure>\n<\/div>\n\n\n<h5 class=\"wp-block-heading has-text-align-center has-afnet-blau-color has-text-color has-link-color wp-elements-adbd8f4f5303b3177e0ad56d1e1f8c63\"><strong><strong>Prof<\/strong>. John Camm<\/strong><\/h5>\n\n\n\n<p class=\"has-text-align-center\">London<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" id=\"infos-studien\">\n<h2 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-a9875f041a7472b8c6e7f51ffec63186\" style=\"text-transform:uppercase\"><strong>Further information<\/strong><\/h2>\n\n\n\n<div class=\"moreinormation-dotted\"> <\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"no-space-studien\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-096b3beeed4d72132b8124649482a4a6\" style=\"text-transform:uppercase\">Registration<\/h4>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-94ed2b0ea851e511f7dc88291052770b\">ClinicalTrials.gov:&nbsp;&nbsp;<a href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01288352?term=NCT01288352&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">NCT01288352<\/a>&nbsp;<\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-4984b4371aced082661b010dc0d217ab\">ISRCTN:&nbsp;&nbsp;<a href=\"http:\/\/www.controlled-trials.com\/ISRCTN04708680\" target=\"_blank\" rel=\"noreferrer noopener\">ISRCTN04708680<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-d64594ffe4a582f1c1def6f66d77236b\">EudraCT:&nbsp;<a href=\"https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query=eudract_number:2010-021258-20\" target=\"_blank\" rel=\"noreferrer noopener\">2010-021258-20<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-cdf0ef5695d8dbcf1d37bcc9f4bdc460\"><a href=\"http:\/\/www.easttrial.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.easttrial.org<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-b191b6c04210b0a0a5e7426a0f4e19e7\" style=\"text-transform:uppercase\">Support<\/h4>\n\n\n\n<p>The trial is supported by<\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-153094786e54f83a35e58b3062ff3d14\"><a href=\"https:\/\/www.de.abbott\/\" target=\"_blank\" rel=\"noreferrer noopener\">Abbott<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-d25dddf785f8a0bc8a20e0b26ecf00e0\"><a href=\"https:\/\/www.escardio.org\/Sub-specialty-communities\/European-Heart-Rhythm-Association-(EHRA)\" target=\"_blank\" rel=\"noreferrer noopener\">European Heart Rhythm Association (EHRA)<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-1095dc6baa9796e3c6b1c301ac977f64\"><a href=\"https:\/\/dzhk.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">Deutsche Zentrum f\u00fcr Herz-Kreislauf-Forschung (DZHK)<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-2fe51cda5cfd89cdad774e49c35ddc45\"><a href=\"https:\/\/www.herzstiftung.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">Deutsche Herzstiftung<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-a67b0fa9e21ea9feffe8aab2b2a161d9\"><a href=\"https:\/\/www.bmbf.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">German Federal Ministry of Education and Research<\/a><\/p>\n\n\n\n<p class=\"has-contrast-color has-text-color has-link-color wp-elements-4ed638ce376c981d3e69d7ae0f6ee94b\"><a href=\"https:\/\/www.sanofi.de\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sanofi<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h4 class=\"wp-block-heading has-afnet-blau-color has-text-color has-link-color wp-elements-b240f9cc480fad0083a9400ca1ac9eed\" style=\"text-transform:uppercase\">sponsor<\/h4>\n\n\n\n<p>Kompetenznetz Vorhofflimmern e.V. (Atrial Fibrillation NETwork, AFNET), M\u00fcnster, Germany<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>EAST-AFNET 4 Early treatment of&nbsp;atrial fibrillation for&nbsp;stroke prevention&nbsp;trial (EAST) study design Investigator-driven, prospective, parallel-group, randomised, open-label trial with blinded-outcome assessment (PROBE-Design). Multi-centre trial for Prevention of Stroke in High-risk Subjects with Atrial Fibillation Inclusion Criteria Recent-onset AF (\u2264 1 year prior to enrolment) At least one ECG within recent 12 months that documents AF whereas &#8230; <a title=\"EAST\" class=\"read-more\" href=\"https:\/\/www.af-net.eu\/en\/east\/\" aria-label=\"Read more about EAST\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_uag_custom_page_level_css":"","iawp_total_views":40,"_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"class_list":["post-11375","page","type-page","status-publish"],"acf":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"timeline-express":false,"timeline-express-thumbnail":false,"1536x1536":false,"2048x2048":false,"vp_sm":false,"vp_md":false,"vp_lg":false,"vp_xl":false,"vp_sm_popup":false,"vp_md_popup":false,"vp_xl_popup":false},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/www.af-net.eu\/en\/author\/cre8ors\/"},"uagb_comment_info":0,"uagb_excerpt":"EAST-AFNET 4 Early treatment of&nbsp;atrial fibrillation for&nbsp;stroke prevention&nbsp;trial (EAST) study design Investigator-driven, prospective, parallel-group, randomised, open-label trial with blinded-outcome assessment (PROBE-Design). Multi-centre trial for Prevention of Stroke in High-risk Subjects with Atrial Fibillation Inclusion Criteria Recent-onset AF (\u2264 1 year prior to enrolment) At least one ECG within recent 12 months that documents AF whereas&hellip;","_links":{"self":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/11375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/comments?post=11375"}],"version-history":[{"count":16,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/11375\/revisions"}],"predecessor-version":[{"id":13253,"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/pages\/11375\/revisions\/13253"}],"wp:attachment":[{"href":"https:\/\/www.af-net.eu\/en\/wp-json\/wp\/v2\/media?parent=11375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}